Mourinho claimed some of his players didn't show up in Saturday's shock 2-1 home defeat to Crystal Palace.
He was also furious with Nemanja Matic, Cesc Fabregas and Branislav Ivanovic, who were all poor against Palace.
But he singled out Hazard in particular for failing to reproduce the form that won him the Footballer of the Year award last season.
Mourinho said: "If you are the best player in the league, I think it should be a good responsibility to have a similar season than in the previous season.
"I don't want to analyse individual performances. In general terms, it is difficult to have a consistent performance when some of the players are not performing at a good level.
IRKED: Mourinho is disappointed with his players
"When you have six or seven performing and three or four who are not at an acceptable level, it is hard for a team to be consistent in the performance."
Asked whether he thought Chelsea have lost their appetite after romping to the title last season, Mourinho said: "If this is real, it is very sad.
"For myself, I feel the opposite. When I win, I want to win again, I want to win more. I feel fantastic motivation for more.
"If you win it once and the next you are not on fire, not ready for at least to fight for more, that is sad.
"You have players who have fantastic seasons and fantastic moments and the next season do not have the same."
Chelsea only lost three games last season but have already lost two this time around - and Mourinho claims no-one is safe from the axe.
He said: "If you ask me: 'Will I accept this, cross my arms, sit in a nice chair and wait calmly for the performance level to be back?' No.
"I have to work, react, analyse and if I feel the players are not in conditions to react and give more, I have to make changes. I have never had a problem with that."
